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・ Phosphoenolpyruvic carboxykinase
・ Phosphoenolpyruvic carboxylase
・ Phosphoethanolamine N-methyltransferase
・ Phosphoethanolamine/phosphocholine phosphatase
・ Phosphofructokinase
・ Phosphofructokinase 1
・ Phosphofructokinase 2
・ Phosphofructokinase deficiency
・ Phosphoglucan, water dikinase
・ Phosphoglucokinase
・ Phosphoglucomutase
・ Phosphoglucomutase (glucose-cofactor)
・ Phosphoglucomutase 3
・ Phosphogluconate 2-dehydrogenase
・ Phosphogluconate dehydratase
Phosphogluconate dehydrogenase
・ Phosphogluconate dehydrogenase (decarboxylating)
・ Phosphoglucosamine mutase
・ Phosphoglycerate
・ Phosphoglycerate dehydrogenase
・ Phosphoglycerate kinase
・ Phosphoglycerate kinase (GTP)
・ Phosphoglycerate mutase
・ Phosphoglycerate phosphatase
・ Phosphoglyceric acid
・ Phosphoglycerol geranylgeranyltransferase
・ Phosphoglycolate phosphatase
・ Phosphogypsum
・ Phosphohydroxypyruvic acid
・ Phosphoinositide 3-kinase


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Phosphogluconate dehydrogenase : ウィキペディア英語版
Phosphogluconate dehydrogenase

Phosphogluconate dehydrogenase is an enzyme in the pentose phosphate pathway. It forms ribulose 5-phosphate from 6-phosphogluconate.
It is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways (PPP). Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequences are highly conserved. The protein is a homodimer in which the monomers act independently:〔 each contains a large, mainly alpha-helical domain and a smaller beta-alpha-beta domain, containing a mixed parallel and anti-parallel 6-stranded beta sheet.〔 NADP is bound in a cleft in the small domain, the substrate binding in an adjacent pocket.〔
Mutations within the gene coding this enzyme result in 6-phosphogluconate dehydrogenase deficiency, an autosomal hereditary disease affecting the red blood cells.
==References==



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